Affiliation:
1. College of Pharmacy, Chosun University, Gwangju 61452, Korea
Abstract
:
Rational drug design is accomplished through the complementary use of structural
biology and computational biology of biological macromolecules involved in disease
pathology. Most of the known theoretical approaches for drug design are based on knowledge
of the biological targets to which the drug binds. This approach can be used to design drug
molecules that restore the balance of the signaling pathway by inhibiting or stimulating
biological targets by molecular modeling procedures as well as by molecular dynamics
simulations. Type III receptor tyrosine kinase affects most of the fundamental cellular processes
including cell cycle, cell migration, cell metabolism, and survival, as well as cell proliferation
and differentiation. Many inhibitors of successful rational drug design show that some
computational techniques can be combined to achieve synergistic effects.
Funder
Korea Institute of Science and Technology Information
National Research Foundation of Korea
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
7 articles.
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