Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase-Reference-Cited by-同舟云学术

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Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase

Published:2015-11-02 Issue:12 Volume:6 Page:1195-1198
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Wills Veronica S.¹,Allen Cheryl²,Holstein Sarah A.²,Wiemer David F.¹³

Affiliation:

1. Department of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, United States

2. Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, United States

3. Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242-1109, United States

Funder

U.S. Department of Health and Human Services

Roy J. Carver Charitable Trust

American Society of Hematology

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00334

Reference17 articles.

1. Human isoprenoid synthase enzymes as therapeutic targets

2. The relationship between the chemistry and biological activity of the bisphosphonates

3. Geranylgeranyl Diphosphate Synthase: An Emerging Therapeutic Target

4. Metabolic control of YAP and TAZ by the mevalonate pathway

5. Synthesis and biological activity of isoprenoid bisphosphonates

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1. Research strategies of small molecules as chemotherapeutics to overcome multiple myeloma resistance;European Journal of Medicinal Chemistry;2024-05

2. α-Amino bisphosphonate triazoles serve as GGDPS inhibitors;Bioorganic & Medicinal Chemistry Letters;2024-04

3. Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer;Journal of Medicinal Chemistry;2023-11-20

4. Structural Insight into Geranylgeranyl Diphosphate Synthase (GGDPS) for Cancer Therapy;Molecular Cancer Therapeutics;2023-09-26

5. Lipid metabolic vulnerabilities of multiple myeloma;Clinical and Experimental Medicine;2023-08-28

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