Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation-Reference-Cited by-同舟云学术

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

Published:2015-05-14 Issue:6 Volume:6 Page:677-682
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

McElroy William T.¹,Tan Zheng¹,Ho Ginny¹,Paliwal Sunil¹,Li Guoqing¹,Seganish W. Michael¹,Tulshian Deen¹,Tata James¹,Fischmann Thierry O.¹,Sondey Christopher¹,Bian Hong¹,Bober Loretta¹,Jackson James¹,Garlisi Charles G.¹,Devito Kristine¹,Fossetta James¹,Lundell Daniel¹,Niu Xiaoda¹

Affiliation:

1. Discovery Chemistry, ‡Structural Chemistry, §In Vitro Pharmacology, and ∥Respiratory and Immunology, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00106

Reference22 articles.

1. Inflammation, ageing and chronic disease

2. Epidemiology and Estimated Population Burden of Selected Autoimmune Diseases in the United States

3. Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts

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5. The problem of choice: current biologic agents and future prospects in RA

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