Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2-Reference-Cited by-同舟云学术

Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2

Published:2022-06-22 Issue:7 Volume:13 Page:1159-1164
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Nguyen Minh H.¹^ORCID,Atasoylu Onur¹,Wu Liangxing¹,Kapilashrami Kanishk¹,Pusey Michelle¹,Gallagher Karen¹,Lai Cheng-Tsung¹,Zhao Peng¹,Barbosa Joseph¹,Liu Kai¹,He Chunhong¹,Zhang Colin¹,Styduhar Evan D.¹,Witten Michael R.¹,Chen Yaoyu¹,Lin Luping¹,Yang Yan-ou¹,Covington Maryanne¹,Diamond Sharon¹,Yeleswaram Swamy¹,Yao Wenqing¹

Affiliation:

1. Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00206

Reference22 articles.

1. TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2. TGFβ–SMAD signal transduction: molecular specificity and functional flexibility

3. Fibrodysplasia Ossificans Progressiva: Clinical Course, Genetic Mutations and Genotype-Phenotype Correlation

4. Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

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