Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2-Reference-Cited by-同舟云学术

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

Published:2024-07-18 Issue:15 Volume:67 Page:12632-12659
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Němec Václav¹²^ORCID,Remeš Marek²^ORCID,Beňovský Petr²,Böck Michael C.²,Šranková Eliška²,Wong Jong Fu³,Cros Julien³^ORCID,Williams Eleanor³,Tse Lap Hang³^ORCID,Smil David⁴^ORCID,Ensan Deeba⁴,Isaac Methvin B.⁴^ORCID,Al-Awar Rima⁴⁵,Gomolková Regina⁶⁷,Ursachi Vlad-Constantin⁶⁸,Fafílek Bohumil⁶⁷⁸,Kahounová Zuzana⁹,Víchová Ráchel⁹,Vacek Ondřej⁸⁹,Berger Benedict-Tilman¹^ORCID,Wells Carrow I.¹⁰,Corona Cesear R.¹¹,Vasta James D.¹¹,Robers Matthew B.¹¹,Krejci Pavel⁶⁷⁸,Souček Karel⁸⁹,Bullock Alex N.³^ORCID,Knapp Stefan¹^ORCID,Paruch Kamil²⁷^ORCID

Affiliation:

1. Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany

2. Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic

3. Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K.

4. Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada

5. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

6. Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic

7. Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic

8. International Clinical Research Center, St. Anne’s University Hospital, 602 00 Brno, Czech Republic

9. Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic

10. Structural Genomics Consortium, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

11. Promega Corporation, Madison, Wisconsin 53716, United States

Funder

Bader Philanthropies

European Commission

Agentura Pro Zdravotnick? V?zkum Cesk? Republiky

Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy

Grantov? Agentura Cesk? Republiky

Masarykova Univerzita

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00629

Reference64 articles.

1. Protein kinases — the major drug targets of the twenty-first century?

2. Imatinib: A Breakthrough of Targeted Therapy in Cancer

3. Kinase drug discovery 20 years after imatinib: progress and future directions

4. Trends in kinase drug discovery: targets, indications and inhibitor design

5. The (un)targeted cancer kinome