From Oxetane to Thietane: Extending the Antiviral Spectrum of 2′-Spirocyclic Uridines by Substituting Oxygen with Sulfur-Reference-Cited by-同舟云学术

From Oxetane to Thietane: Extending the Antiviral Spectrum of 2′-Spirocyclic Uridines by Substituting Oxygen with Sulfur

Published:2022-11-28 Issue:12 Volume:13 Page:1879-1884
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Grosse Sandrine¹^ORCID,Tahri Abdellah¹,Raboisson Pierre¹,Houpis Yannis¹,Stoops Bart¹,Jacoby Edgar¹,Neefs Jean-Marc¹,Van Loock Marnix²,Goethals Olivia²,Geluykens Peggy³,Bonfanti Jean-François⁴,Jonckers Tim H. M.¹

Affiliation:

1. Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium

2. Janssen Global Public Health, R&D, Turnhoutseweg 30, 2340 Beerse, Belgium

3. Charles River, Discovery, Turnhoutseweg 30, 2340 Beerse, Belgium

4. Janssen Research and Development, Chaussée du Vexin, 27100 Val de Reuil, France

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00372

Reference40 articles.

1. Drug Discovery of Nucleos(t)ide Antiviral Agents: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Birthday

2. Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

3. EASL recommendations on treatment of hepatitis C: Final update of the series☆

4. Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases–Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection

5. https://www.veklury.com, consulted 2022/09/26.

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1. Oxetanes in Drug Discovery Campaigns;Journal of Medicinal Chemistry;2023-09-07

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