Inhibition of β-Amyloid Aggregation in Alzheimer’s Disease: The Key Role of (Pro)electrophilic Warheads-Reference-Cited by-同舟云学术

Inhibition of β-Amyloid Aggregation in Alzheimer’s Disease: The Key Role of (Pro)electrophilic Warheads

Published:2022-10-10 Issue:11 Volume:13 Page:1812-1818
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Basagni Filippo¹^ORCID,Naldi Marina¹,Ginex Tiziana²^ORCID,Luque F. Javier²^ORCID,Fagiani Francesca³,Lanni Cristina³,Iurlo Matteo⁴,Marcaccio Massimo⁴^ORCID,Minarini Anna¹,Bartolini Manuela¹^ORCID,Rosini Michela¹^ORCID

Affiliation:

1. Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy

2. Department of Nutrition, Food Science, and Gastronomy, Institute of Biomedicine (IBUB) and Institute of Theoretical and Computational Chemistry (IQTCUB), University of Barcelona, Avinguda Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain

3. Department of Drug Sciences (Pharmacology Section), University of Pavia, V.le Taramelli 14, 27100 Pavia, Italy

4. Department of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum - University of Bologna, Via Selmi 2, 40126 Bologna, Italy

Funder

Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali

Ministero dell?Istruzione, dell?Universit? e della Ricerca

Consorci de Serveis Universitaris de Catalunya

Agencia Estatal de Investigaci?n,Ministerio de Ciencia, Innovaci?n y UniversidadesAgencia Estatal de Investigaci?n,Ministerio de Ciencia, Innovaci?n y Universidades

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00410

Reference26 articles.

1. Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species

2. Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

3. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

4. Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms

5. Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

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