Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics-Reference-Cited by-同舟云学术

Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics

Published:2022-05-10 Issue:6 Volume:13 Page:949-954
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Garsi Jean-Baptiste¹,Komjáti Balázs²,Cullia Gregorio¹,Fejes Imre²,Sipos Melinda²,Sipos Zoltán²,Fördős Eszter²,Markacz Piroska²,Balázs Barbara²,Lancelot Nathalie³,Berger Sylvie³,Raimbaud Eric³,Brown David³,Vuillard Laurent-Michel³,Haberkorn Laure³,Cukier Cyprian⁴,Szlávik Zoltán²,Hanessian Stephen¹⁵^ORCID

Affiliation:

1. Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Centre-Ville, Montréal, QC H2V 0B3, Canada

2. Servier Research Institute of Medicinal Chemistry, 1031 Záhony utca 7 Mb, Budapest 1031, Hungary

3. Institut de Recherche Servier, 125 Chemin de la Ronde, 78290 Croissy, France

4. Selvita S.A., ul. Bobrzyńskiego 14, 30-348 Kraków, Poland

5. Department of Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92617, USA

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00094

Reference51 articles.

1. NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress

2. The Neutrophil NADPH Oxidase

3. The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

4. NADPH Oxidase: An Update

5. Activation and assembly of the NADPH oxidase: a structural perspective

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