Targeting NOX2 with Bivalent Small-Molecule p47phox–p22phox Inhibitors-Reference-Cited by-同舟云学术

Targeting NOX2 with Bivalent Small-Molecule p47phox–p22phox Inhibitors

Published:2023-10-19 Issue:21 Volume:66 Page:14963-15005
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zang Jie¹,Peters Felix¹,Cambet Yves²,Cifuentes-Pagano Eugenia³⁴,Hissabu Munira Mohamed Shishay¹,Dustin Christopher M.³⁴,Svensson Lars Henrik¹,Olesen Martin Mariboe¹,Poulsen Mathias Feldt Lomholt¹,Jacobsen Stig¹,Tuelung Pernille Sønderby¹^ORCID,Narayanan Dilip¹,Langkilde Annette Eva¹^ORCID,Gajhede Michael¹^ORCID,Pagano Patrick J.³⁴,Jaquet Vincent²⁵,Vilhardt Frederik⁶,Bach Anders¹^ORCID

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark

2. READS unit, Centre Médical Universitaire, University of Geneva, Geneva CH-1211, Switzerland

3. Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States

4. Department of Pharmacology and ChemicalBiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States

5. Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Geneva CH-1211, Switzerland

6. Institute of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark

Funder

Novo Nordisk Fonden

China Scholarship Council

Gigtforeningen

Lundbeck Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01548

Reference94 articles.

1. The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

2. NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress

3. Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

4. On the Clinical Pharmacology of Reactive Oxygen Species

5. NOX Inhibitors: From Bench to Naxibs to Bedside

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