Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin-Reference-Cited by-同舟云学术

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

Published:2017-02-11 Issue:3 Volume:8 Page:321-326
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Metcalf Brian¹,Chuang Chihyuan²,Dufu Kobina¹,Patel Mira P.¹,Silva-Garcia Abel¹,Johnson Carl¹,Lu Qing²,Partridge James R.¹,Patskovska Larysa³,Patskovsky Yury³,Almo Steven C.³,Jacobson Matthew P.⁴^ORCID,Hua Lan⁴,Xu Qing¹,Gwaltney Stephen L.¹,Yee Calvin¹,Harris Jason¹,Morgan Bradley P.²,James Joyce²,Xu Donghong²,Hutchaleelaha Athiwat¹,Paulvannan Kumar⁵,Oksenberg Donna¹,Li Zhe¹^ORCID

Affiliation:

1. Global Blood Therapeutics, Inc., South San Francisco, California 94080, United States

2. Cytokinetics, Inc., South San Francisco, California 94080, United States

3. Albert Einstein College of Medicine, Bronx, New York 10461, United States

4. Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States

5. Tandem Sciences, Inc., Menlo Park, California 94025, United States

Funder

National Institute of General Medical Sciences

National Science Foundation

University of Texas MD Anderson Cancer Center

Plexxikon Inc.

Publisher