Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist
Author:
Affiliation:
1. Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad-382 210, India
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00331
Reference27 articles.
1. From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
2. Pathophysiology and Treatment of Diabetic Peripheral Neuropathy: The Case for Diabetic Neurovascular Function as an Essential Component
3. Non-insulin therapies for type 2 diabetes
4. Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
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