Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design-Reference-Cited by-同舟云学术

Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design

Published:2016-09-20 Issue:12 Volume:7 Page:1124-1129
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Welsch Matthew E.¹,Zhou Jian²,Gao Yueqiang²,Yan Yunqing²,Porter Gene³,Agnihotri Gautam³,Li Yingjie²,Lu Henry²,Chen Zhongguo²,Thomas Stephen B.¹

Affiliation:

1. Turing Pharmaceuticals AG, Research & Development, 1177 Avenue of the Americas, 39th Floor, New York, New York 10036, United States

2. WuXi AppTec, International Discovery Service Unit & Research Service Division, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

3. WuXi AppTec, In Vitro Biology US, 107 Morgan Lane, Plainsborough, New Jersey 08536, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00328

Reference26 articles.

1. Evasion of innate immunity by parasitic protozoa

2. Host Cell Invasion by Apicomplexan Parasites: The Junction Conundrum

3. First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling

4. Targeting DHFR in parasitic protozoa

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