First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling-Reference-Cited by-同舟云学术

First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling

Published:2013-10-03 Issue:41 Volume:52 Page:7305-7317
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Sharma Hitesh¹,Landau Mark J.¹,Vargo Melissa A.¹,Spasov Krasimir A.¹,Anderson Karen S.¹

Affiliation:

1. The Departments of Pharmacology and §Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Conneticut 06510, United States

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi400576t

Reference51 articles.

1. Dihydrofolate reductase as a therapeutic target for infectious diseases: opportunities and challenges

2. Recent Advances in Classical and Non-Classical Antifolates as Antitumor and Antiopportunistic Infection Agents: Part I

3. Atomic Structure of Thymidylate Synthase: Target for Rational Drug Design

4. Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site

5. Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Computational screening of FDA-approved drugs to identify potential TgDHFR, TgPRS, and TgCDPK1 proteins inhibitors against Toxoplasma gondii;Scientific Reports;2023-04-03

2. Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies;Metabolites;2022-12-21

3. Single- and duplex TaqMan-quantitative PCR for determining the copy numbers of integrated selection markers during site-specific mutagenesis in Toxoplasma gondii by CRISPR-Cas9;PLOS ONE;2022-09-16

4. Single- and duplex TaqMan-quantitative PCR for determining the copy numbers of integrated selection markers during site-specific mutagenesis in Toxoplasma gondii by CRISPR-Cas9;2022-06-23

5. Structural Insight into Effective Inhibitors’ Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase;ACS Chemical Biology;2022-06-17