Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum
Author:
Affiliation:
1. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
2. Division of Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
Funder
National Institute of Allergy and Infectious Diseases
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00416
Reference22 articles.
1. Thousands of chemical starting points for antimalarial lead identification
2. Chemical genetics of Plasmodium falciparum
3. World Health Organization. AntimalarialDrug Resistance. http://www.who.int/malaria/areas/drug_resistance/overview/en/(October 2014) .
4. Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance
5. Quinoline anti-malarial drugs inhibit spontaneous formation of β-haematin (malaria pigment)
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