Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement-Reference-Cited by-同舟云学术

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

Published:2016-09-28 Issue:12 Volume:7 Page:1062-1067
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Marx Isaac E.¹,Dineen Thomas A.¹,Able Jessica¹,Bode Christiane¹,Bregman Howard¹,Chu-Moyer Margaret¹,DiMauro Erin F.¹,Du Bingfan¹,Foti Robert S.¹,Fremeau Robert T.¹,Gao Hua¹,Gunaydin Hakan¹,Hall Brian E.¹,Huang Liyue¹,Kornecook Thomas¹,Kreiman Charles R.¹,La Daniel S.¹,Ligutti Joseph¹,Lin Min-Hwa Jasmine¹,Liu Dong¹,McDermott Jeff S.¹,Moyer Bryan D.¹,Peterson Emily A.¹,Roberts Jonathan T.¹,Rose Paul¹,Wang Jean¹,Youngblood Beth D.¹,Yu Violeta¹,Weiss Matthew M.¹

Affiliation:

1. Department of Medicinal Chemistry, ‡Department of Molecular Engineering, §Department of Pharmacokinetics and Drug Metabolism, ∥Department of Neuroscience, and ⊥Department of Biologics, Amgen, Inc., 360 Binney Street, Cambridge, Massachusetts 02142, and One Amgen Center Drive, Thousand Oaks, California 91320, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00243

Reference14 articles.

1. Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons

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5. Voltage-gated sodium channels and pain pathways

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