Discovery of pyridyl urea sulfonamide inhibitors of NaV1.7-Reference-Cited by-同舟云学术

Discovery of pyridyl urea sulfonamide inhibitors of NaV1.7

Published:2022-10 Issue: Volume:73 Page:128892
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Butler John R.,Rescourio Gwenaella,Milgram Benjamin C.,Foti Robert S.,Kornecook Thomas,Ligutti Joseph,Moyer Bryan D.,Taborn Kristin,Youngblood Beth D.,Yu Violeta,Shimanovich Roman,Boezio Alessandro,Weiss Matthew

Funder

Amgen Inc

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

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3. Among potential off-target effects associated with other isoforms, Nav1.5 expression in cardiac tissue represents a key risk.

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