Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations-Reference-Cited by-同舟云学术

Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations

Published:2016-02-11 Issue:4 Volume:7 Page:418-423
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Sabbavarapu Narayana Murthy¹,Shavit Michal¹,Degani Yarden¹,Smolkin Boris¹,Belakhov Valery¹,Baasov Timor¹

Affiliation:

1. The Edith and Joseph Fischer Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry, Technion−Israel Institute of Technology, Haifa 32000, Israel

Funder

Ministry of Science and Technology, Israel

Eloxx Pharmaceutical LTD Research Fund

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00006

Reference20 articles.

1. Pharmacological Suppression of Premature Stop Mutations that Cause Genetic Diseases

2. Aminoglycoside-induced Translational Read-through in Disease: Overcoming Nonsense Mutations by Pharmacogenetic Therapy

3. Therapeutics Based on Stop Codon Readthrough

4. When proteins start to make sense: fine-tuning of aminoglycosides for PTC suppression therapy

5. Increased Selectivity toward Cytoplasmic versus Mitochondrial Ribosome Confers Improved Efficiency of Synthetic Aminoglycosides in Fixing Damaged Genes: A Strategy for Treatment of Genetic Diseases Caused by Nonsense Mutations

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