Synthesis, Inhibitory Activity, and In Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core-Reference-Cited by-同舟云学术

Synthesis, Inhibitory Activity, and In Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core

Published:2021-03-12 Issue:4 Volume:12 Page:610-616
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Dvorakova Marcela¹^ORCID,Langhansova Lenka¹^ORCID,Temml Veronika²^ORCID,Pavicic Antonio¹,Vanek Tomas¹,Landa Premysl¹^ORCID

Affiliation:

1. Laboratory of Plant Biotechnologies, Czech Academy of Sciences, Institute of Experimental Botany, Rozvojova 263, 165 02 Prague 6 - Lysolaje, Czech Republic

2. Department of Pharmaceutical and Medicinal Chemistry, Paracelsus Medical University of Salzburg, Strubergasse 21, 5020 Salzburg, Austria

Funder

Austrian Science Fund

Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00004

Reference33 articles.

1. Comparison of the Peroxidase Reaction Kinetics of Prostaglandin H Synthase-1 and -2

2. Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)

3. Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer

4. Selective COX-1 Inhibition: A Therapeutic Target to be Reconsidered

5. Selective Cyclooxygenase-1 Inhibition by P6 and Gastrotoxicity: Preliminary Investigation

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