Identification, Synthesis, and Characterization of a Major Circulating Human Metabolite of TRPV4 Antagonist GSK2798745
Author:
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00406
Reference17 articles.
1. Preclinicalin vivoADME studies in drug development: a critical review
2. Pharmacologically Active Drug Metabolites: Impact on Drug Discovery and Pharmacotherapy
3. Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)
4. Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects
5. Targeting pulmonary capillary permeability to reduce lung congestion in heart failure: a randomized, controlled pilot trial
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