Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Cardiology and Cardiovascular Medicine,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s40256-018-00320-6.pdf
Reference8 articles.
1. Thorneloe KS, Cheung M, Bao W, et al. An orally active TRPV4 channel blocker prevents and resolves pulmonary oedema induced by heart failure. Sci Transl Med. 2012;4(159):159ra148.
2. Yang L, Maki-Petaja K, Cheriyan J, McEniery C, Wilkinson IB. The role of epoxyeicosatrienoic acids in the cardiovascular system. Br J Clin Pharmacol. 2015;80:28–44.
3. US Food and Drug Administration Guidance for Industry. Food-effect bioavailability and fed bioequivalence studies. December 2002.
4. Everaerts W, Nilius B, Owsianik G. The vallinoid transient receptor potential channel TRPV4: from structure to disease. Prog Biophys Mol Biol. 2010;103:2–17.
5. Alvarez DF, King JA, Weber D, Addison E, Liedtke W, Townsley MI. Transient receptor vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. Circ Res. 2006;99:988–95.
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