Novel Pyridazin-3(2<i>H</i>)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity-Reference-Cited by-同舟云学术

Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity

Published:2022-02-10 Issue:3 Volume:13 Page:463-469
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Costas-Lago María Carmen¹²,Vila Noemí¹²,Rahman Adeyemi³,Besada Pedro¹²,Rozas Isabel³^ORCID,Brea José⁴,Loza María Isabel⁴^ORCID,González-Romero Elisa⁵^ORCID,Terán Carmen¹²^ORCID

Affiliation:

1. Departamento de Química Orgánica, Universidade de Vigo, 36310 Vigo, España

2. Instituto de Investigación Sanitaria Galicia Sur, Hospital Álvaro Cunqueiro, 36213 Vigo, España

3. School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland

4. Drug Screening Platform/Biofarma Research Group, CIMUS Research Center. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica. Universidade de Santiago de Compostela, 15782 Santiago de Compostela, España

5. Departamento de Química Analítica y Alimentaria, Universidade de Vigo, 36310 Vigo, España

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00633

Reference30 articles.

1. Recent developments in compounds acting in the DNA minor groove

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4. Crystal structures of B-form DNA–RNA chimers complexed with distamycin

5. Crystallographic insights into DNA minor groove recognition by drugs

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