Serendipitous <i>N</i>,<i>S</i>-difunctionalization of triazoles with trifluoromethyl-β-diketones: access to regioisomeric 1-trifluoroacetyl-3-aryl-5-(2-oxo-2-arylethylthio)-1,2,4-triazoles as DNA-groove binders-Reference-Cited by-同舟云学术

Serendipitous N,S-difunctionalization of triazoles with trifluoromethyl-β-diketones: access to regioisomeric 1-trifluoroacetyl-3-aryl-5-(2-oxo-2-arylethylthio)-1,2,4-triazoles as DNA-groove binders

Published:2024 Issue:10 Volume:14 Page:6738-6751
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Aggarwal Ranjana¹²^ORCID,Kumar Prince¹^ORCID,Hooda Mona³^ORCID,Kumar Suresh¹^ORCID

Affiliation:

1. Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Haryana, India

2. Council of Scientific and Industrial Research-National Institute of Science Communication and Policy Research, New Delhi 110012, India

3. Department of Chemistry, Gurugram University, Gurugram-122003, Haryana, India

Abstract

An expedient construction of DNA groove binder; CF3-containing triazoles via regioselective reaction of trifluoromethyl-β-diketones with 3-mercapto[1,2,4]triazoles.

Funder

Human Resource Development Centre, Council of Scientific And Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA00083H

Reference41 articles.

1. Contribution of Organofluorine Compounds to Pharmaceuticals

2. Reducing the Lipophilicity of Perfluoroalkyl Groups by CF2–F/CF2–Me or CF3/CH3 Exchange

3. p-Toluenesulfonic acid-catalyzed solvent-free synthesis and biological evaluation of new 1-(4′,6′-dimethylpyrimidin-2′-yl)-5-amino-4H-3-arylpyrazole derivatives

4. Transition-metal-free, visible-light-mediated regioselective C–H trifluoromethylation of imidazo[1,2-a]pyridines

5. FDA-Approved Trifluoromethyl Group-Containing Drugs: A Review of 20 Years