Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi-Reference-Cited by-同舟云学术

Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi

Published:2019-09-09 Issue:3 Volume:11 Page:278-285
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Varghese Swapna¹^ORCID,Rahmani Raphaël¹,Russell Stephanie²,Deora Girdhar Singh¹^ORCID,Ferrins Lori¹^ORCID,Toynton Arthur²,Jones Amy³,Sykes Melissa³,Kessler Albane⁴,Eufrásio Amanda⁵,Cordeiro Artur Torres⁵,Sherman Julian⁶,Rodriguez Ana⁶,Avery Vicky M.³,Piggott Matthew J.²^ORCID,Baell Jonathan B.⁷¹⁸⁹^ORCID

Affiliation:

1. Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

2. Chemistry, School of Molecular Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia

3. Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, Queensland 4111, Australia

4. GlaxoSmithKline, 28760 Tres Cantos, Spain

5. Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, São Paulo 13083-970, Brazil

6. Anti-Infectives Screening Core, New York University School of Medicine, New York 10016, United States

7. School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China

8. ARC Centre for Fragment-Based Design, Monash University, Parkville, Victoria 3052, Australia

9. Australian Translational Medicinal Chemistry Facility (ATMCF), Monash University, Parkville, Victoria 3052, Australia

Funder

National Health and Medical Research Council

Griffith University

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00218

Reference19 articles.

1. Neglected tropical diseases; World Health Organisation; http://www.who.int/neglected_diseases/diseases/en/.

2. The development of drugs for treatment of sleeping sickness: a historical review

3. Sleeping sickness is a circadian disorder

4. Trypanosomiasis, human African (sleeping sickness), Fact Sheet; https://www.who.int/news-room/fact-sheets/detail/trypanosomiasis-human-african-(sleeping-sickness) (accessed 5 October 2018).

5. Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis and Anti-Trypanosoma cruzi Activity of New Pyrazole-Thiadiazole Scaffolds;Molecules;2024-07-27

2. Privileged small molecules against neglected tropical diseases: A perspective from structure activity relationships;European Journal of Medicinal Chemistry;2024-05

3. Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection;Journal of Medicinal Chemistry;2023-01-06

4. Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease;European Journal of Medicinal Chemistry;2023-01

5. Hybrid-Compounds Against Trypanosomiases;Current Drug Targets;2022-10