Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an <i>In Vivo</i> Model of <i>Trypanosoma cruzi</i> Infection-Reference-Cited by-同舟云学术

Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection

Published:2023-01-06 Issue:2 Volume:66 Page:1221-1238
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tawaraishi Taisuke¹,Ochida Atsuko¹,Akao Yuichiro¹,Itono Sachiko¹,Kamaura Masahiro¹,Akther Thamina¹,Shimada Mitsuyuki¹,Canan Stacie²,Chowdhury Sanjoy³,Cao Yafeng⁴,Condroski Kevin²^ORCID,Engkvist Ola⁵^ORCID,Francisco Amanda⁶,Ghosh Sunil³,Kaki Rina⁷,Kelly John M.⁶,Kimura Chiaki⁷,Kogej Thierry⁵,Nagaoka Kazuya⁸,Naito Akira⁷,Pairaudeau Garry⁹,Radu Constantin¹⁰,Roberts Ieuan⁹,Shum David¹⁰,Watanabe Nao-aki⁸,Xie Huanxu⁴,Yonezawa Shuji⁷,Yoshida Osamu⁷,Yoshida Ryu⁷,Mowbray Charles¹¹^ORCID,Perry Benjamin¹¹^ORCID

Affiliation:

1. Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chrome, Fujisawa, Kanagawa 251-8555, Japan

2. Celgene Corporation, Celgene Global Health, 10300 Campus Point Drive, San Diego, California 92121, United States

3. TCG Lifesciences, Plot No-7, Salt Lake Electronics Complex, BN Block, Sector V, Kolkata 700091, India

4. WuXi AppTec Company Ltd., 666 Gaoxin Road, East Lake High-Tech Development Zone, Wuhan 430075, People’s Republic of China

5. AstraZeneca Discovery Sciences, R&D, Pepparedsleden 1, 431 50 Mölndal, Sweden

6. London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.

7. Shionogi & Co., Ltd, 3-1-1, Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan

8. Eisai Co., Ltd, 1-3, Tokodai 5-chome, Tsukuba, Ibaraki 300-2635, Japan

9. AstraZeneca, Discovery Sciences, R&D, The Darwin Building, 310 Milton Road, Milton, Cambridge CB4 0WG, U.K.

10. Institut Pasteur Korea, 16, Daewangpangyo-ro 712 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea

11. Drugs for Neglected Diseases Initiative, 15 Chemin Camille Vidart, Geneva 1202, Switzerland

Funder

Global Health Innovative Technology Fund

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00775

Reference61 articles.

1. Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

2. Determinants of disease phenotype in trypanosomatid parasites

3. Updated Estimates and Mapping for Prevalence of Chagas Disease among Adults, United States

4. Some Aspects of Protozoan Infections in Immunocompromised Patients: A Review

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