Discovery of [1,2,4]Triazolo[1,5-a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists-Reference-Cited by-同舟云学术

Discovery of [1,2,4]Triazolo[1,5-a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists

Published:2020-02-27 Issue:4 Volume:11 Page:528-534
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Nakajima Ryota¹^ORCID,Oono Hiroyuki¹,Sugiyama Sakae¹,Matsueda Yohei¹,Ida Tomohide¹,Kakuda Shinji¹,Hirata Jun¹,Baba Atsushi¹,Makino Akito¹,Matsuyama Ryo¹,White Ryan D.²,Wurz Ryan Ρ.³^ORCID,Shin Youngsook³,Min Xiaoshan,Guzman-Perez Angel²,Wang Zhulun,Symons Antony,Singh Sanjay K.⁴,Mothe Srinivasa Reddy⁴,Belyakov Sergei⁴,Chakrabarti Anjan⁴,Shuto Satoshi^ORCID

Affiliation:

1. Teijin Institute for Bio-medical Research, Teijin Pharma Limited, 4-3-2 Asahigaoka, Hino, Tokyo 191-8512, Japan

2. Department of Medicinal Chemistry, Amgen Discovery Research, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States

3. Department of Medicinal Chemistry, Amgen Discovery Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States

4. AMRI Singapore Research Centre, Pte. Ltd., 61 Science Park Road, #05-01 The Galen, Science Park III, Singapore 117525

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00649

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