Discovery of New 1,1′-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors-Reference-Cited by-同舟云学术

Discovery of New 1,1′-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors

Published:2019-11-11 Issue:5 Volume:11 Page:633-637
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

La Regina Giuseppe¹^ORCID,Puxeddu Michela¹,Nalli Marianna¹,Vullo Daniela²,Gratteri Paola³^ORCID,Supuran Claudiu Trandafir²^ORCID,Nocentini Alessio²³^ORCID,Silvestri Romano¹^ORCID

Affiliation:

1. Laboratory affiliated to Istitut Pasteur Italy − Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy

2. NEUROFARBA Department − Pharmaceutical and Nutraceutical Section, University of Firenze, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Firenze, Italy

3. NEUROFARBA Department − Pharmaceutical and Nutraceutical Section; Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Firenze, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Firenze, Italy

Funder

Ministero dell'Istruzione, dell'Universit? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00437

Reference18 articles.

1. Carbonic anhydrases

2. Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

3. The zinc coordination pattern in the η-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families

4. Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery

5. Interfering with pH regulation in tumours as a therapeutic strategy

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