Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity
Author:
Affiliation:
1. Genentech, Inc., One DNA Way, South San Francisco, California 94080, United States
2. WuXi Apptech, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00380
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3. Recent Advances in the Discovery of Small Molecule Inhibitors of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) as a Therapeutic Target for Inflammation and Oncology Disorders
4. Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling
5. Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling
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