Quick Building Blocks (QBB): An Innovative and Efficient Business Model To Speed Medicinal Chemistry Analog Synthesis-Reference-Cited by-同舟云学术

Quick Building Blocks (QBB): An Innovative and Efficient Business Model To Speed Medicinal Chemistry Analog Synthesis

Published:2019-07-05 Issue:8 Volume:10 Page:1104-1109
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Helal Christopher J.¹^ORCID,Bundesmann Mark¹,Hammond Susan¹,Holmstrom Melissa²,Klug-McLeod Jacquelyn¹,Lefker Bruce A.³,McLeod Dale¹,Subramanyam Chakrapani¹,Zakaryants Oleg⁴,Sakata Sylvie²

Affiliation:

1. Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States

2. Worldwide Research and Development, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States

3. Worldwide Research and Development, Pfizer Inc., 1 Portland Square, Cambridge, Massachusetts 02139, United States

4. MilliporeSigma, 6000 N. Teutonia Avenue, Milwaukee, Wisconsin 53209, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00205

Reference23 articles.

1. Organic synthesis provides opportunities to transform drug discovery

2. Expanding the medicinal chemistry synthetic toolbox

3. The importance of synthetic chemistry in the pharmaceutical industry

4. Designing novel building blocks is an overlooked strategy to improve compound quality

5. Increased building block access through collaboration

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