Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2-Reference-Cited by-同舟云学术

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Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2

Published:2019-08-19 Issue:9 Volume:10 Page:1266-1271
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Serafim Ricardo A. M.¹²,de Souza Gama Fernando H.³,Dutra Luiz A.¹²,dos Reis Caio V.¹²,Vasconcelos Stanley N. S.¹²,da Silva Santiago André¹²,Takarada Jéssica E.¹²,Di Pillo Fúlvia⁴,Azevedo Hatylas³,Mascarello Alessandra³,Elkins Jonathan M.²⁵,Massirer Katlin B.¹²,Gileadi Opher⁵,Guimarães Cristiano R. W.³,Couñago Rafael M.¹²^ORCID

Affiliation:

1. Centro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas (UNICAMP), Campinas, SP 13083-875, Brazil

2. Structural Genomics Consortium, Departamento de Genética e Evolução, Instituto de Biologia, UNICAMP, Campinas, SP 13083-886, Brazil

3. Aché Laboratórios Farmacêuticos S.A., Guarulhos, SP, Brazil

4. PhD Program in Genetics and Molecular Biology (PGBM), UNICAMP, Campinas, SP 13083-886, Brazil

5. Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, U.K.

Funder

Merck

Merck KGaA

Bayer

Pfizer

Ontario Ministry of Economic Development and Innovation

Genome Canada

Wellcome Trust

AbbVie

Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo

University of North Carolina

Johnson and Johnson

Boehringer Ingelheim

Canada Foundation for Innovation

Novartis

Takeda Pharmaceutical Company

Minist??rio da Ci??ncia, Tecnologia e Inova????o

Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior

Embrapii

Innovative Medicines Initiative

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00082

Reference25 articles.

1. Characterization of Three Paralogous Members of the Mammalian Vaccinia Related Kinase Family

2. Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

3. Mitotic Histone H3 Phosphorylation by Vaccinia-Related Kinase 1 in Mammalian Cells

4. Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomes

5. Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression

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