Recent Advances and Outlook for the Isosteric Replacement of Anilines
Author:
Affiliation:
1. Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States
Funder
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00687
Reference18 articles.
1. Bioactivation of Drugs: Risk and Drug Design
2. Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States
3. Should the Incorporation of Structural Alerts be Restricted in Drug Design? An Analysis of Structure-Toxicity Trends with Aniline-Based Drugs
4. Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks
5. The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?
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