Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1H-benzimidazol-2-ones as mGlu2 Receptor PAMs-Reference-Cited by-同舟云学术

Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1H-benzimidazol-2-ones as mGlu2 Receptor PAMs

Published:2019-10-10 Issue:3 Volume:11 Page:303-308
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

de Lucas Ana Isabel¹,Vega Juan Antonio¹,Matesanz Encarnación¹,Linares María Lourdes¹,García Molina Aránzazu¹,Tresadern Gary²^ORCID,Lavreysen Hilde³,Trabanco Andrés A.¹^ORCID,Cid José María¹^ORCID

Affiliation:

1. Discovery Chemistry, Janssen Research & Development, Division of Janssen-Cilag S.A., Jarama 75A, Toledo 45007, Spain

2. Computational Chemistry, Discovery Neuroscience, Janssen Research & Development, Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium

3. Discovery Neuroscience, Janssen Research & Development, Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00350

Reference22 articles.

1. Ionotropic and metabotropic glutamate receptor structure and pharmacology

2. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

3. Structure, Pharmacology and Therapeutic Prospects of Family C G-Protein Coupled Receptors

4. Positive Allosteric Modulators for mGluR2 Receptors: A Medicinal Chemistry Perspective

5. mGluR2 positive allosteric modulators: a patent review (2009 – present)

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