LogD Contributions of Substituents Commonly Used in Medicinal Chemistry
Author:
Affiliation:
1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States
Funder
Genentech
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00489
Reference27 articles.
1. Lipophilicity in drug discovery
2. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
3. A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs
4. An analysis of the attrition of drug candidates from four major pharmaceutical companies
5. A Novel Method for High Throughput Lipophilicity Determination by Microscale Shake Flask and Liquid Chromatography Tandem Mass Spectrometry
Cited by 39 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Discovery of in silico pharmacokinetic characteristics, drug-likeness, computational and experimental pKa values of selected unnatural fatty acid derivatives;Phosphorus, Sulfur, and Silicon and the Related Elements;2024-08-28
2. Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for In Vivo Efficacy against Neisseria gonorrhoeae;Journal of Medicinal Chemistry;2024-08-14
3. Emerging contaminants as unintentional substances in paper and board: A case of unexpected pharmaceuticals detection in the paper recycling chain;Journal of Hazardous Materials;2024-07
4. Deriving insights for molecular design with MMP analysis;Trends in Chemistry;2024-07
5. The role of the methoxy group in approved drugs;European Journal of Medicinal Chemistry;2024-07
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3