Lowering Lipophilicity by Adding Carbon: AzaSpiroHeptanes, a logD Lowering Twist
Author:
Affiliation:
1. Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00248
Reference27 articles.
1. Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines
2. Spirocyclic Oxetanes: Synthesis and Properties
3. Synthesis of Azaspirocycles and their Evaluation in Drug Discovery
4. A high throughput dried DMSO LogD lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection
5. Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma
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