Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology-Reference-Cited by-同舟云学术

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology

Published:2024-01-08 Issue: Volume: Page:
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Poudel Yam B.¹^ORCID,He Liqi¹,Cox Matthew¹,Zhang Qian¹,Johnson Walter L.¹,Cong Qiang¹,Cheng Heng¹^ORCID,Chowdari Naidu S.¹,Tarby Christine²,Donnell Andrew F.²^ORCID,Broekema Matthais²,O’Malley Daniel P.²^ORCID,Zhang Yong²^ORCID,A. M. Subbaiah Murugaiah³^ORCID,Kumar Boda Vijay³,Subramani Lakshumanan³,Wang Bei²,Li Yi-Xin¹,Sivaprakasam Prasanna²^ORCID,Critton David²,Mulligan Dawn²,Sandhu Bhupindar²,Xie Chunshan²,Ramakrishnan Radha²,Nagar Jignesh³,Dudhgaonkar Shailesh³,Oderinde Martins S.²^ORCID,Murtaza Anwar²,Schieven Gary L.²,Mathur Arvind²,Gavai Ashvinikumar V.²^ORCID,Vite Gregory²,Gangwar Sanjeev¹

Affiliation:

1. Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States

2. Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States

3. The Biocon Bristol Myers Squibb Research Center (BBRC), Bangalore 560099, India

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00455

Reference25 articles.

1. Cancer immunotherapy comes of age

2. Cancer immunotherapy using checkpoint blockade

3. Turning cold tumors hot: from molecular mechanisms to clinical applications

4. Pattern Recognition Receptors and Inflammation

5. TLR agonists: our best frenemy in cancer immunotherapy

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology;ACS Medicinal Chemistry Letters;2024-01-09