Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793
Author:
Affiliation:
1. Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States
Funder
Janssen Research and Development
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00085
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1. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
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3. The hypocretins/orexins: integrators of multiple physiological functions
4. Motivational activation: a unifying hypothesis of orexin/hypocretin function
5. The role of orexin in motivated behaviours
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