Identification of Highly Selective Orexin 1 Receptor Antagonists Driven by Structure-Based Design
Author:
Affiliation:
1. Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397 Biberach an der Riss, Germany
2. Boehringer Ingelheim Research Italia S.a.s. di BI IT S.r.l., Via Giovanni Lorenzini 8, 20139 Milano, MI, Italy
Publisher
American Chemical Society (ACS)
Subject
Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c01055
Reference54 articles.
1. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
2. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
3. Differential expression of orexin receptors 1 and 2 in the rat brain
4. The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
5. Narcolepsy in orexin Knockout Mice
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