Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1
Author:
Affiliation:
1. H3 Biomedicine Inc., 300 Technology Square, Fifth Floor, Cambridge, Massachusetts 02139, United States
Funder
H3 Biomedicine Inc
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00145
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1. Ammonium metabolism in humans
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3. p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis
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5. Role of CPS1 in Cell Growth, Metabolism, and Prognosis in LKB1-Inactivated Lung Adenocarcinoma
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