Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18-Reference-Cited by-同舟云学术

Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18

Published:2020-06-17 Issue:10 Volume:11 Page:2024-2031
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Schoeder Clara T.¹²,Mahardhika Andhika B.¹²^ORCID,Drabczyńska Anna³,Kieć-Kononowicz Katarzyna³,Müller Christa E.¹^ORCID

Affiliation:

1. Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn 53121, Germany

2. Research Training Group 1873, University of Bonn, 53127 Bonn, Germany

3. Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland

Funder

Bundesministerium f?r Bildung und Forschung

European Commission

Uniwersytet Jagiellonski Collegium Medicum

Deutsche Forschungsgemeinschaft

Bayer HealthCare

Ministery of Finance of Indonesia

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00208

Reference44 articles.

1. The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

2. Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18

3. Identification of resolvin D2 receptor mediating resolution of infections and organ protection

4. GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment

5. Cloning and Chromosomal Localization of a Gene (GPR18) Encoding a Novel Seven Transmembrane Receptor Highly Expressed in Spleen and Testis

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