Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease-Reference-Cited by-同舟云学术

Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

Published:2020-04-27 Issue:6 Volume:11 Page:1257-1268
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Ratni Hasane¹^ORCID,Alker Andre¹,Bartels Bjoern¹,Bissantz Caterina¹,Chen Weichun²,Gerlach Irene¹,Limberg Anja¹,Lu Mingqiu²,Neidhart Werner¹,Pichereau Solen¹,Reutlinger Michael¹,Rodriguez-Sarmiento Rosa-Maria¹,Jakob-Roetne Roland¹,Schmitt Georg¹,Zhang Eric²,Baumann Karlheinz¹

Affiliation:

1. F. Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland

2. F. Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, Roche Innovation Center Shanghai, Cai Lun Road 720, 201203 Shanghai, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00109

Reference20 articles.

1. Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

2. Amyloid deposition as the central event in the aetiology of Alzheimer's disease

3. A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

4. Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved

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