Discovery and SAR of Novel Disubstituted Quinazolines as Dual PI3Kalpha/mTOR Inhibitors Targeting Breast Cancer-Reference-Cited by-同舟云学术

Discovery and SAR of Novel Disubstituted Quinazolines as Dual PI3Kalpha/mTOR Inhibitors Targeting Breast Cancer

Published:2020-10-12 Issue:11 Volume:11 Page:2156-2164
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Al-Ashmawy Aisha A. K.¹²^ORCID,Elokely Khaled M.¹³⁴,Perez-Leal Oscar¹,Rico Mario¹,Gordon John¹,Mateo George¹,Omar Abdelsattar M.⁵⁶^ORCID,Abou-Gharbia Magid¹^ORCID,Childers Wayne E.¹

Affiliation:

1. Moulder Center for Drug Discovery Research, Temple University, School of Pharmacy, 3307 N. Broad Street, Philadelphia, Pennsylvania 19140, United States

2. Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Center, Dokki, Cairo 12622, Egypt

3. Department of Pharmaceutical Chemistry, Tanta University, Tanta 31527, Egypt

4. Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York 11201, United States

5. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Alsulaymanyah, Jeddah 21589, Saudi Arabia

6. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt

Funder

Ministry of Higher Education

United States Agency for International Development

Deanship of Scientific Research, King Abdulaziz University, Jeddah, Saudia Arabia

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00289

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5. Mutation of the PIK3CA Gene in Ovarian and Breast Cancer

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