Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase δ-Reference-Cited by-同舟云学术

Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase δ

Published:2020-06-03 Issue:7 Volume:11 Page:1386-1391
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Spencer Jonathan A.¹²,Baldwin Ian R.¹,Barton Nick¹,Chung Chun-Wa¹^ORCID,Convery Máire A.¹,Edwards Christopher D.¹,Jamieson Craig²^ORCID,Mallett David N.¹,Rowedder James E.¹,Rowland Paul¹,Thomas Daniel A.¹,Hardy Charlotte J.¹^ORCID

Affiliation:

1. GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom

2. Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom

Funder

Engineering and Physical Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00061

Reference24 articles.

1. Inhibition of PI3K Signaling Spurs New Therapeutic Opportunities in Inflammatory/Autoimmune Diseases and Hematological Malignancies

2. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

3. Small-molecule inhibitors of the PI3K signaling network

4. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease

5. PI 3-kinase inhibition: a therapeutic target for respiratory disease

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Missing Link(er): A Roadmap to Macrocyclization in Drug Discovery;Journal of Medicinal Chemistry;2024-08-22

2. Macrocyclization strategy for improving candidate profiles in medicinal chemistry;European Journal of Medicinal Chemistry;2024-06

3. Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ;Nature Structural & Molecular Biology;2024-04-02

4. Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ;2023-05-05

5. Turning down PI3K/AKT/mTOR signalling pathway by natural products: an in silico multi-target approach;SAR and QSAR in Environmental Research;2023-02-01