Engineering Selectivity for Reduced Toxicity of Bacterial Kinase Inhibitors Using Structure-Guided Medicinal Chemistry-Reference-Cited by-同舟云学术

Engineering Selectivity for Reduced Toxicity of Bacterial Kinase Inhibitors Using Structure-Guided Medicinal Chemistry

Published:2021-01-13 Issue:2 Volume:12 Page:228-235
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Wlodarchak Nathan¹²^ORCID,Feltenberger John B.³,Ye Zhengqing³^ORCID,Beczkiewicz Jeffrey²,Procknow Rebecca²,Yan Gang⁴,King Troy M.²,Golden Jennifer E.³⁴^ORCID,Striker Rob¹²^ORCID

Affiliation:

1. William S. Middleton Veterans Hospital, 2500 Overlook Terrace, Madison, Wisconsin 53705, United States

2. Department of Medicine, University of Wisconsin-Madison, 1550 Linden Drive, Madison, Wisconsin 53706, United States

3. University of Wisconsin-Madison Medicinal Chemistry Center, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, Wisconsin 53705, United States

4. Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, Wisconsin 53705, United States

Funder

U.S. Department of Veterans Affairs

American Heart Association

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00580

Reference40 articles.

1. Global Tuberculosis Report 2020; World Health Organization, 2020.

2. Treatment Outcomes of Patients With Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis According to Drug Susceptibility Testing to First- and Second-line Drugs: An Individual Patient Data Meta-analysis