Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors
Author:
Affiliation:
1. Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, Massachusetts 02210, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00573
Reference22 articles.
1. The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases
2. The Phosphoinositide 3-Kinase Pathway
3. The emerging mechanisms of isoform-specific PI3K signalling
4. Synthesis and Function of 3-Phosphorylated Inositol Lipids
5. Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
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