Using Transcriptomics and Cell Morphology Data in Drug Discovery: The Long Road to Practice-Reference-Cited by-同舟云学术

Using Transcriptomics and Cell Morphology Data in Drug Discovery: The Long Road to Practice

Published:2023-03-22 Issue:4 Volume:14 Page:386-395
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Pruteanu Lavinia-Lorena¹²,Bender Andreas³^ORCID

Affiliation:

1. Department of Chemistry and Biology, North University Center at Baia Mare, Technical University of Cluj-Napoca, Victoriei 76, 430122 Baia Mare, Romania

2. Research Center for Functional Genomics, Biomedicine, and Translational Medicine, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania

3. Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00015

Reference79 articles.

1. High-dimensional gene expression and morphology profiles of cells across 28,000 genetic and chemical perturbations

2. Predicting drug polypharmacology from cell morphology readouts using variational autoencoder latent space arithmetic

3. Pooled genetic screens with image‐based profiling

4. When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

5. Predictive validity in drug discovery: what it is, why it matters and how to improve it

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