Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide-Reference-Cited by-同舟云学术

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Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide

Published:2023-11-10 Issue:12 Volume:14 Page:1833-1838
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Ohba Yusuke¹,Adachi Kaoru¹,Furukawa Takayuki¹,Nishimaru Tatsuya¹,Sakurai Kentaro¹,Masuo Ritsuki¹,Inami Tasuku¹,Orita Takuya¹,Akai Shota¹,Adachi Tsuyoshi¹,Usui Kenji¹,Hamada Yuji¹,Mori Mutsuki¹,Kurimoto Takafumi¹,Wakashima Takeshi¹,Akiyama Yoshiyuki¹,Miyazaki Susumu¹,Noji Satoru¹^ORCID

Affiliation:

1. Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki Osaka 569-1125, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00433

Reference24 articles.

1. The NLRP3 inflammasome: molecular activation and regulation to therapeutics

2. Inflammasomes: mechanism of action, role in disease, and therapeutics

3. NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma

4. The Role of Inflammasomes in Glomerulonephritis

5. Targeting the NLRP3 inflammasome in inflammatory diseases

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