Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors-Reference-Cited by-同舟云学术

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Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors

Published:2023-10-03 Issue:10 Volume:14 Page:1441-1447
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Buchholz Caroline R.¹,Sneddon Molly S.²,McPherson Joseph E.¹,Das Sourav³,Gee Clifford T.³,Grillo Michael J.¹,Chai Sergio C.³^ORCID,Lee Richard E.³^ORCID,Chen Taosheng³^ORCID,Harki Daniel A.¹^ORCID,Shelat Anang A.³^ORCID,Pomerantz William C. K.¹²^ORCID

Affiliation:

1. Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States

2. Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States

3. Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

Funder

U.S. Department of Health and Human Services

American Foundation for Pharmaceutical Education

American Lebanese Syrian Associated Charities

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00343

Reference31 articles.

1. Methyl-Readers and Inhibitors

2. The PHD finger: a versatile epigenome reader

3. Handpicking epigenetic marks with PHD fingers

4. PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

5. Recurrent abnormalities can be used for risk group stratification in pediatric AMKL: a retrospective intergroup study

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