<i>N</i>-Aryl Indoles as a Novel Class of Potent Na<sub>V</sub>1.7 Inhibitors-Reference-Cited by-同舟云学术

N-Aryl Indoles as a Novel Class of Potent Na_V1.7 Inhibitors

Published:2023-05-24 Issue:6 Volume:14 Page:788-793
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Karanjule Narayan¹,Hayashi Noriyuki¹,Suzuki Sayaka¹,Tsuda Toshifumi¹,Tokumaru Eri¹,Tanaka Kyosuke¹,Kimoto Hiroko¹,Domon Yuki¹,Takahashi Sakiko¹,Kubota Kazufumi¹,Kitano Yutaka¹,Yokoyama Tomihisa¹,Koishi Ryuta²,Fujiwara Chie¹,Inaba Shinichi¹,Asano Daigo¹,Sakakura Tomoko¹,Takasuna Kiyoshi¹,Shinozuka Tsuyoshi¹^ORCID

Affiliation:

1. Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

2. Daiichi Sankyo RD Novare Co., Ltd., 1-16-13, Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00079

Reference16 articles.

1. An SCN9A channelopathy causes congenital inability to experience pain

2. Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

3. Efficacy of the Nav1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy

4. Inhibition of Na_V1.7: the possibility of ideal analgesics

5. Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7

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