Optimization of a β-Lactam Scaffold for Antibacterial Activity via the Inhibition of Bacterial Type I Signal Peptidase-Reference-Cited by-同舟云学术

Optimization of a β-Lactam Scaffold for Antibacterial Activity via the Inhibition of Bacterial Type I Signal Peptidase

Published:2018-03-15 Issue:4 Volume:9 Page:376-380
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Yeh Chien-Hung¹^ORCID,Walsh Shawn I.¹,Craney Arryn¹,Tabor M. Greg¹,Voica Ana-Florina¹,Adhikary Ramkrishna¹^ORCID,Morris Sydney E.¹,Romesberg Floyd E.¹^ORCID

Affiliation:

1. Department of Chemistry, The Scripps Research Institute, La Jolla California 92037 United States

Funder

Division of Graduate Education

National Institute of Allergy and Infectious Diseases

Natural Sciences and Engineering Research Council of Canada

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00064

Reference49 articles.

1. Drugs for bad bugs: confronting the challenges of antibacterial discovery

2. Historical and changing epidemiology of healthcare-associated infections

3. Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy

4. Synthetic Inhibitors of Elastase

5. Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase

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