Peptidomimetics for Targeting Protein–Protein Interactions between DOT1L and MLL Oncofusion Proteins AF9 and ENL-Reference-Cited by-同舟云学术

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Peptidomimetics for Targeting Protein–Protein Interactions between DOT1L and MLL Oncofusion Proteins AF9 and ENL

Published:2018-08-06 Issue:9 Volume:9 Page:895-900
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Du Lei¹,Grigsby Sierrah M.,Yao Aihong¹,Chang Yujie¹,Johnson Garrett,Sun Haiying¹^ORCID,Nikolovska-Coleska Zaneta^ORCID

Affiliation:

1. Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

Funder

University of Michigan

Innovative Team of Jiangsu Province

Division of Graduate Education

Government of Jiangsu Province

Center for the Discovery of New Medicines, University of Michigan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00175

Reference19 articles.

1. The Pathogenesis of Mixed-Lineage Leukemia

2. Transcriptional activation by MLL fusion proteins in leukemogenesis

3. MLL translocations, histone modifications and leukaemia stem-cell development

4. AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

5. A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription

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1. Structural studies of intrinsically disordered MLL‐fusion protein AF9 in complex with peptidomimetic inhibitors;Protein Science;2024-05-15

2. Rational design of small-sized peptidomimetic inhibitors disrupting protein–protein interaction;RSC Medicinal Chemistry;2024

3. Discovery, Structure–Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein–Protein Interactions between AF9/ENL and AF4 or DOT1L;Cancers;2023-11-03

4. The YEATS domain epigenetic reader proteins ENL and AF9 and their therapeutic value in leukemia;Experimental Hematology;2023-08

5. The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia;Leukemia;2022-11-26

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