Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase
Author:
Affiliation:
1. Pfizer Worldwide Research and Development, La Jolla Oncology, 10770 Science Center Drive, San Diego, California 92121, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00348
Reference40 articles.
1. Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition
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5. Emergence of New ALK Mutations at Relapse of Neuroblastoma
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